Protection against a parasitic infection

"We were excited that our findings appeared to relate kidney disease in the United States with human evolution and parasite infection in Africa," said Pollak. "While there are many details that remain to be clarified in future studies, we do know that sickle-cell disease is a well-established precedent for this model, in which one copy of the mutation confers protection against a parasitic infection but two copies of the mutation can cause severe disease."

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